Synthesis of 14C-Pentachlorophenol.

Pentachlorophenol and By-products of Its Synthesis

The complex mixture pentachlorophenol and by-products of its synthesis is reasonably anticipated to be a human carcinogen based on limited evidence of carcinogenicity from studies in humans and sufficient evidence of carcinogenicity from studies in experimental animals. This conclusion is supported by mechanistic studies whose findings are consistent with the biological plausibility of its carc...

Synthesis of 14C-labeled alkyl polyoxyethylene detergents.

Procedures for the synthesis and purification of two 14C-labeled alkyl polyoxyethylene detergent preparations are described. One of the preparations consisted mainly of [14C]dodecyloctaoxyethylene ether, the other consisted mainly of [14C] octylhexaoxyethylene ether, with critical micellar concentrations of approximately 50 microM and 10 mM, respectively. Condensation of alkyl bromides with fra...

A facile synthesis of [14C] epicholesterol.

A facile procedure is described for the preparation of [14C]epicholesterol from [14C]cholesterol. Cholesterol is first converted to cholesteryl mesylate, which is treated with cesium acetate and 18-crown-6 in refluxing toluene to give epicholesteryl acetate. The latter is hydrolyzed, without isolation, with potassium hydroxide in tetrahydrofuran-methanol to give epicholesterol, which is obtaine...

Stimulation of(14C)serotonin synthesis from (14C)tryptophan by mescaline in rat pineal organ cultures.

substrate. Mescaline does not inhibit the deandnation of [14C] serotonin to 5-hydroxyindoleacetic acid and has no significant effect on the intracellular content of [14C] tryptophan or its conversion to [14G] protein. It is • 14 concluded that mescaline stimulates p_ne;¢l [ C] serotonin synthesis via a primary stimula£ory action on the enzymatic conversion of [14.C]tryptophan to 5-hydroxytrypto...

Synthesis of 2-(4-methoxyphenyl)ethanol[ring-1-14C].